On Thanksgiving Night, the leading team in the NFC West, the San Francisco 49ers (7-3 SU, 5-5 ATS), will face off against the second-place Seattle Seahawks (6-4, 5-4-1) as the favored team on the road. The 49ers have recently bounced back from a three-game losing streak, winning their last two games against the Jacksonville Jaguars and Tampa Bay Buccaneers with an impressive score margin of 61-17. Although they have only covered the spread in one of these games, both matches were characterized by low-scoring affairs.

49ers vs Seahawks Odds Insights

  • San Francisco are 4-2 against the spread (ATS) when playing Seattle.
  • The 49ers have gone 2-5 ATS in their last seven games on the road.
  • The Seahawks are 6-3 straight up (SU) and 5-1 ATS against the NFC.
  • The total has gone UNDER in 7 of Seattle's last 9 games on a Thursday.
The San Francisco 49ers are favored in betting picks on the road against the Seattle Seahawks.

49ers vs Seahawks Game Summary

On Thanksgiving Night, the revitalized San Francisco 49ers will journey to Seattle to face off against the Seahawks in a game that holds significant implications for both the division and playoffs. Following a three-game losing streak, the 49ers have bounced back impressively, winning two consecutive games after their bye week. Meanwhile, the Seahawks, who now have a record of 6-4, are one game behind the 49ers after suffering their second defeat of the season at the hands of the Rams on Sunday.

Injury Report

49ers: S Talanoa Hufanga (knee) is out. G Aaron Banks (toe), G Spencer Burford (knee) are doubtful. DT Javon Hargrave (thumb), CB Shemar Jean-Charles (shoulder), WR Ray-Ray McCloud (rib) are questionable.

Seahawks: WR Jake Bobo (shoulder), RB Kenneth Walker III (oblique), S Jerrick Reed II (knee) are all doubtful. QB Geno Smith (right elbow), WR Dareke Young (abdomen), WR Tyler Lockett (hamstring), S Jamal Adams (knee/NIR-Resting player), CB Riq Woolen (shoulder), CB Tre Brown (foot), CB/S Coby Bryant (toe) are all questionable.

San Francisco Betting Predictions

The 49ers have returned to their dominant form following a three-game losing streak prior to their bye week. They convincingly defeated the Jaguars 34-3 two weeks ago and continued their winning streak with a 27-14 victory over the Buccaneers on Sunday. However, they were unable to cover the spread and have a 1-4 record against the spread in their last five games.

Interestingly, it has been almost a decade since the Niners last played on Thanksgiving, and unfortunately, they suffered a 19-3 defeat against the Seahawks on that occasion. Despite this setback, the 49ers hold a 30-20 advantage in the all-time series against their fierce rivals. Impressively, they have emerged victorious in their last three encounters, including a playoff win last year, with an average winning margin of 15.3 points.

Seattle Betting Picks

Seattle relinquished a 16-7 advantage to their division rival Rams, however, they may have suffered additional setbacks with the injuries sustained by Geno Smith (elbow) and Kenneth Williams (oblique). Presently, they are confronted with a swift turnaround as they prepare to face another NFC West opponent, the 49ers.

Historically, the Seahawks have a 2-2 record on Thanksgiving, and this game will be their first since 2014 when they emerged victorious against the 49ers. Additionally, they will be returning to their home ground where they have a solid 4-1 record, although their performance against the spread stands at 2-3. On the other hand, the over has prevailed in 3 out of 5 games at Lumen Field and has been successful in the last two encounters.

49ers vs Seahawks Predictions

San Francisco -7 (-115): The Niners have emerged victorious in three consecutive encounters between these two teams, triumphing with an average point differential of over 15. The Seahawks, on the other hand, enter this match having thrown the ball the sixth most times per game in the NFL. However, they will now face this challenge with a less-than-100% Geno Smith.

Although it appears that Smith will start, the initial reports are not as positive for WR TJ Lockett, S Jamal Adams, and RB Kenneth Walker III. Going up against the Niners, especially in their current form, is already a daunting task, but attempting to compete with an injured squad is more than the Seahawks can handle.

Purdy performed exceptionally well last season during the team's victory in Seattle, a notoriously difficult home-field advantage, so I anticipate him having no difficulties on Thursday night either. Expect the Niners to cover the spread and secure a victory by a margin of ten or more points.